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The catalytic domains of PDE3A and B are remarkably conserved, besides for an insertion of forty four special amino acids that is not observed in the catalytic domains of other PDE households and that also differs in, and hence distinguishes, PDE3A and B isoforms

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This interaction is crucial for the correct orientation of the C2 acetamido group and...
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True-time RTPCR analyses uncovered that expressions of osteoblastic differentiation markers variety I collagen (Col I), osteopontin, ALP, and osteocalcin had been up-controlled by the GSK-3b insufficiency, while the differentiation markers of mesenchymal progenitors Twist-one

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Movement cytometry was carried out on an EPICS Xl (Coulter Beckman) employing EXPO 32TGR-1202...
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It has been hypothesized that either the accumulation of damaged proteins in methyltransferase knockouts acts as a immediate switch activating insulin signaling or that the methyltransferase may immediately interfere with the insulin-signaling pathway unbiased of isoaspartyl accumulation

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Significant concentration of XZH-5 did not lead to overall body bodyweight loss in mice1354825-62-9...