Product Name :
Benzamil
Description:
Benzamil (Benzylamiloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM.
CAS:
2898-76-2
Molecular Weight:
319.75
Formula:
C13H14ClN7O
Chemical Name:
3, 5-diamino-N-(N-benzylcarbamimidoyl)-6-chloropyrazine-2-carboxamide
Smiles :
NC1=NC(N)=C(N=C1Cl)C(=O)NC(=N)NCC1C=CC=CC=1
InChiKey:
KXDROGADUISDGY-UHFFFAOYSA-N
InChi :
InChI=1S/C13H14ClN7O/c14-9-11(16)20-10(15)8(19-9)12(22)21-13(17)18-6-7-4-2-1-3-5-7/h1-5H,6H2,(H4,15,16,20)(H3,17,18,21,22)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Benzamil (Benzylamiloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.Auranofin Purity & Documentation 1 μM.|Product information|CAS Number: 2898-76-2|Molecular Weight: 319.75|Formula: C13H14ClN7O|Chemical Name: 3, 5-diamino-N-(N-benzylcarbamimidoyl)-6-chloropyrazine-2-carboxamide|Smiles: NC1=NC(N)=C(N=C1Cl)C(=O)NC(=N)NCC1C=CC=CC=1|InChiKey: KXDROGADUISDGY-UHFFFAOYSA-N|InChi: InChI=1S/C13H14ClN7O/c14-9-11(16)20-10(15)8(19-9)12(22)21-13(17)18-6-7-4-2-1-3-5-7/h1-5H,6H2,(H4,15,16,20)(H3,17,18,21,22)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Pralatrexate Apoptosis |Shelf Life: ≥12 months if stored properly.PMID:32757126 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Benzamil (Benzylamiloride) inhibits neuronal and heterologously expressed small conductance Ca2+-activated K2+ channels.|In Vivo:|Benzamil (Benzylamiloride) (0.7 mg/kg/day; s.c.) treated stroke-prone spontaneously hypertensive rats (SHRSP) survived, on average, until 16.1 weeks of age in SHRSP rats.|Products are for research use only. Not for human use.|
