Product Name :
WYC-209
Description:
WYC-209, a synthetic retinoid, is a retinoic acid receptor (RAR) agonist. WYC-209 induces apoptosis primarily via the caspase 3 pathway (IC50=0.19 μM for inmalignant murine melanoma TRCs), and has long-term effects with little toxicity.
CAS:
2131803-90-0
Molecular Weight:
368.45
Formula:
C20H20N2O3S
Chemical Name:
ethyl 2-[2-(4,4-dimethyl-1-oxo-3,4-dihydro-2H-1λ⁴-benzothiopyran-6-yl)ethynyl]pyrimidine-5-carboxylate
Smiles :
CCOC(=O)C1=CN=C(C#CC2C=C3C(=CC=2)S(=O)CCC3(C)C)N=C1
InChiKey:
LLMDAYVUHYVJSS-UHFFFAOYSA-N
InChi :
InChI=1S/C20H20N2O3S/c1-4-25-19(23)15-12-21-18(22-13-15)8-6-14-5-7-17-16(11-14)20(2,3)9-10-26(17)24/h5,7,11-13H,4,9-10H2,1-3H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
WYC-209, a synthetic retinoid, is a retinoic acid receptor (RAR) agonist. WYC-209 induces apoptosis primarily via the caspase 3 pathway (IC50=0.Otamixaban supplier 19 μM for inmalignant murine melanoma TRCs), and has long-term effects with little toxicity.LL-37 amide web |Product information|CAS Number: 2131803-90-0|Molecular Weight: 368.PMID:33306168 45|Formula: C20H20N2O3S|Chemical Name: ethyl 2-[2-(4,4-dimethyl-1-oxo-3,4-dihydro-2H-1λ⁴-benzothiopyran-6-yl)ethynyl]pyrimidine-5-carboxylate|Smiles: CCOC(=O)C1=CN=C(C#CC2C=C3C(=CC=2)S(=O)CCC3(C)C)N=C1|InChiKey: LLMDAYVUHYVJSS-UHFFFAOYSA-N|InChi: InChI=1S/C20H20N2O3S/c1-4-25-19(23)15-12-21-18(22-13-15)8-6-14-5-7-17-16(11-14)20(2,3)9-10-26(17)24/h5,7,11-13H,4,9-10H2,1-3H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 83.33 mg/mL (226.16 mM; Need ultrasonic). H2O : Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|WYC-209 (10 μM; 24 hours) is able to inhibit and block growth of TRCs of human tumor cells in culture with a long-lasting effect.|In Vivo:|WYC-209 (0.022-0.22 mg/kg; i.v.; once every two days for 25 days) inhibits tumor metastasis in C57BL/6 mice bearing lung metastases.|Products are for research use only. Not for human use.|
