Product Name :
CP-547632
Description:
CP-547632 is an orally active, ATP-competitive and potent VEGFR-2 and FGF kinases inhibitor with IC50s of 11 nM and 9 nM, respectively. CP-547632 is selective for VEGFR2 and bFGF over EGFR, PDGFRβ, and related tyrosine kinases (TKs). CP-547632 has antitumor efficacy.
CAS:
252003-65-9
Molecular Weight:
532.40
Formula:
C20H24BrF2N5O3S
Chemical Name:
3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-([4-(pyrrolidin-1-yl)butyl]carbamoylamino)-1,2-thiazole-4-carboxamide
Smiles :
NC(=O)C1=C(NC(=O)NCCCCN2CCCC2)SN=C1OCC1C(F)=CC(Br)=CC=1F
InChiKey:
HXHAJRMTJXHJJZ-UHFFFAOYSA-N
InChi :
InChI=1S/C20H24BrF2N5O3S/c21-12-9-14(22)13(15(23)10-12)11-31-18-16(17(24)29)19(32-27-18)26-20(30)25-5-1-2-6-28-7-3-4-8-28/h9-10H,1-8,11H2,(H2,24,29)(H2,25,26,30)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CP-547632 is an orally active, ATP-competitive and potent VEGFR-2 and FGF kinases inhibitor with IC50s of 11 nM and 9 nM, respectively. CP-547632 is selective for VEGFR2 and bFGF over EGFR, PDGFRβ, and related tyrosine kinases (TKs).Minoxidil Purity CP-547632 has antitumor efficacy.Kahweol MedChemExpress |Product information|CAS Number: 252003-65-9|Molecular Weight: 532.PMID:32981709 40|Formula: C20H24BrF2N5O3S|Chemical Name: 3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-([4-(pyrrolidin-1-yl)butyl]carbamoylamino)-1,2-thiazole-4-carboxamide|Smiles: NC(=O)C1=C(NC(=O)NCCCCN2CCCC2)SN=C1OCC1C(F)=CC(Br)=CC=1F|InChiKey: HXHAJRMTJXHJJZ-UHFFFAOYSA-N|InChi: InChI=1S/C20H24BrF2N5O3S/c21-12-9-14(22)13(15(23)10-12)11-31-18-16(17(24)29)19(32-27-18)26-20(30)25-5-1-2-6-28-7-3-4-8-28/h9-10H,1-8,11H2,(H2,24,29)(H2,25,26,30)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (187.83 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CP-547632 (1-1000 nM; 1 hours) inhibits VEGF-stimulated VEGFR-2 phosphorylation in a dose-dependent fashion, with an IC50 value of 6 nM.|In Vivo:|CP-547632 (p.o.; 6.25-100 mg/kg/day; for 10-24 days) causes a dose-dependent inhibition of growth in Colo-205, DLD-1, and MDA-MB-231 xenografts. CP-547632 (oral; 50 mg/kg; a single oral dose) yieldes plasma concentrations above 500 ng/ml for 12 hours.|Products are for research use only. Not for human use.|
