Product Name :
NBQX disodium
Description:
NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity.
CAS:
479347-86-9
Molecular Weight:
380.24
Formula:
C12H6N4Na2O6S
Chemical Name:
disodium 6-nitro-2,3-dioxo-7-sulfamoyl-1H,2H,3H,4H-benzo[f]quinoxaline-1,4-diide
Smiles :
[Na+].[Na+].NS(=O)(=O)C1=CC=CC2=C1C(=CC1[N-]C(=O)C(=O)[N-]C=12)[N+]([O-])=O
InChiKey:
XFHCQLPOJLVQQE-UHFFFAOYSA-L
InChi :
InChI=1S/C12H8N4O6S.2Na/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6;;/h1-4H,(H4,13,14,15,17,18,21,22);;/q;2*+1/p-2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.MDTF In stock
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity.|Product information|CAS Number: 479347-86-9|Molecular Weight: 380.24|Formula: C12H6N4Na2O6S|Synonym:|FG9202 disodium|Chemical Name: disodium 6-nitro-2,3-dioxo-7-sulfamoyl-1H,2H,3H,4H-benzo[f]quinoxaline-1,4-diide|Smiles: [Na+].[Na+].NS(=O)(=O)C1=CC=CC2=C1C(=CC1[N-]C(=O)C(=O)[N-]C=12)[N+]([O-])=O|InChiKey: XFHCQLPOJLVQQE-UHFFFAOYSA-L|InChi: InChI=1S/C12H8N4O6S.2Na/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6;;/h1-4H,(H4,13,14,15,17,18,21,22);;/q;2*+1/p-2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Surfactin Bacterial |Shelf Life: ≥12 months if stored properly.PMID:31840538 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|NBQX disodium (FG9202 disodium) has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex.|In Vivo:|NBQX disodium (FG9202; 20 mg/kg, i.p.; for 3 days) decreases seizures induced by PTZ. NBQX disodium is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion.|References:|Fukushima K, et al. Characterization of Human Hippocampal Neural Stem/Progenitor Cells and Their Application to Physiologically Relevant Assays for Multiple Ionotropic Glutamate Receptors. J Biomol Screen. 2014 Sep; 19(8):1174-84.Wen Chen, et al. AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets. PLoS One. 2016 Nov 23;11(11):e0166672.Products are for research use only. Not for human use.|
