Product Name :
N,N-Dimethylsphingosine, D-erythro
Sequence:
Purity:
≥98% (TLC)
Molecular Weight:
327.6
Solubility :
Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).
Appearance:
White to off-white waxy solid or viscous oil.
Use/Stability :
As indicated on product label or CoA when stored as recommended.{{2381089-83-2} medchemexpress|{2381089-83-2} Purity & Documentation|{2381089-83-2} Formula|{2381089-83-2} manufacturer} Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Description:
Sphingosine kinase inhibitor Potent and specific inhibitor of sphingosine kinase (IC50=5µM) which blocks conversion of sphingosine to sphingosine-1-phosphate .{{2238831-60-0} medchemexpress|{2238831-60-0} Technical Information|{2238831-60-0} In Vitro|{2238831-60-0} supplier} Inhibitor of protein kinase C (PKC) which also stimulates Src-kinase. May affect expression of cell surface selectins, which in turn mediate leukocyte or tumor cell adhesion to endothelial cells and platelets. Induces apoptosis. Stereospecifically induces EGF receptor autophosphorylation producing EGF-like activity in vitro in the absence of EGF.PMID:29999848 Produced endogenously via ceramide catabolism. May be a target for neuropathic pain therapy.
CAS :
119567-63-4
Solubility:
Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).
Formula:
C20H41NO2
Additional Information :
| Alternative Name N,N-Dimethyl-D-erythro-sphingosine | Appearance White to off-white waxy solid or viscous oil. | CAS 119567-63-4 | Couple Target PKC, Sphingosine kinase | Couple Type Inhibitor | Formula C20H41NO2 | MW 327.6 | Purity ≥98% (TLC) | Solubility Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml). | Source Synthetic. | Technical Info / Product Notes Note: Product is not sterile | Unit of Measure (UM) mg
