Product Name :
Fosifloxuridine nafalbenamide
Description:
Fosifloxuridine nafalbenamide (NUC-3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. Fosifloxuridine nafalbenamide has anticancer activity. Fosifloxuridine nafalbenamide has the potential to evoke a host immune response and enhance immunotherapy.
CAS:
1332837-31-6
Molecular Weight:
613.53
Formula:
C29H29FN3O9P
Chemical Name:
benzyl (2S)-2-[({[(2R,3S,5R)-5-(5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy}(naphthalen-1-yloxy)phosphoryl)amino]propanoate
Smiles :
C[C@H](NP(=O)(OC1=CC=CC2=CC=CC=C21)OC[C@H]1O[C@H](C[C@@H]1O)N1C=C(F)C(=O)NC1=O)C(=O)OCC1C=CC=CC=1
InChiKey:
BIOWRMNRHMERIO-ZVAHOJSLSA-N
InChi :
InChI=1S/C29H29FN3O9P/c1-18(28(36)39-16-19-8-3-2-4-9-19)32-43(38,42-24-13-7-11-20-10-5-6-12-21(20)24)40-17-25-23(34)14-26(41-25)33-15-22(30)27(35)31-29(33)37/h2-13,15,18,23,25-26,34H,14,16-17H2,1H3,(H,32,38)(H,31,35,37)/t18-,23-,25+,26+,43?/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Fosifloxuridine nafalbenamide (NUC-3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. Fosifloxuridine nafalbenamide has anticancer activity. Fosifloxuridine nafalbenamide has the potential to evoke a host immune response and enhance immunotherapy.|Product information|CAS Number: 1332837-31-6|Molecular Weight: 613.{{Thioridazine} medchemexpress|{Thioridazine} Neuronal Signaling|{Thioridazine} Protocol|{Thioridazine} Purity|{Thioridazine} custom synthesis|{Thioridazine} Autophagy} 53|Formula: C29H29FN3O9P|Chemical Name: benzyl (2S)-2-[({[(2R,3S,5R)-5-(5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy}(naphthalen-1-yloxy)phosphoryl)amino]propanoate|Smiles: C[C@H](NP(=O)(OC1=CC=CC2=CC=CC=C21)OC[C@H]1O[C@H](C[C@@H]1O)N1C=C(F)C(=O)NC1=O)C(=O)OCC1C=CC=CC=1|InChiKey: BIOWRMNRHMERIO-ZVAHOJSLSA-N|InChi: InChI=1S/C29H29FN3O9P/c1-18(28(36)39-16-19-8-3-2-4-9-19)32-43(38,42-24-13-7-11-20-10-5-6-12-21(20)24)40-17-25-23(34)14-26(41-25)33-15-22(30)27(35)31-29(33)37/h2-13,15,18,23,25-26,34H,14,16-17H2,1H3,(H,32,38)(H,31,35,37)/t18-,23-,25+,26+,43?/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (162.{{Fmoc-Ser(tBu)-OH} web|{Fmoc-Ser(tBu)-OH} {Amino Acid Derivatives}|{Fmoc-Ser(tBu)-OH} Immunology/Inflammation|{Fmoc-Ser(tBu)-OH} Biological Activity|{Fmoc-Ser(tBu)-OH} In Vivo|{Fmoc-Ser(tBu)-OH} supplier} 99 mM; Need ultrasonic).PMID:27108903 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Fosifloxuridine nafalbenamide induces the release of damage-associated molecular patterns (DAMPs), with increased expression of calreticulin (CRT) at the cell surface and concomitant loss of nuclear nuclear high mobility group box protein 1 (HMGB1).|In Vivo:|Fosifloxuridine nafalbenamide exhibits anti-cancer activity in HT-29 nude mouse xenograft models.|Products are for research use only. Not for human use.|
