Product Name :
SB 202474
Description:
SB 202474 is a structural analog of SB 202190 and SB 203580 that is used as a negative control in researches of p38 inhibition. SB 202190 and SB 203580 are potent and selective inhibitors of the MAP kinases p38α and p38β . Mitogen-activated protein kinases (MAPKs) are ser/thr-specific protein kinases that regulate gene expression, proliferation, differentiation, cell survival and apoptosis. Three most widely characterized MAPK subfamilies are ERK1/2, JNK and p38MAPK, of which JNK and p38MAPK are identified as a stress-activated protein kinase (SAPK) that primarily mediates inflammatory response and promotes cell death . SB 202474 is a structural analog of SB 202190 and SB 203580 that is used as a negative control in researches of p38 inhibition. In 3T3-L1 adipocytes and L6 myotubes, SB203580 but not SB202474 prevented insulin-stimulated glucose transport . Pretreatment with microinjection into the bilateral rostral ventrolateral medulla (RVLM) of SB203580 (2 nmol) significantly exacerbated the depressor effect and blunted the augmented power density of the LF component of SAP signals during the pro-life phase. SB203580 also significantly shortened the pro-life phase to 60 min. SB202474 (2 nmol) was ineffective against the phasic cardiovascular responses in the aCSF-control group or Mev-experimental group .{{Enfortumab vedotin-ejfv (solution)} site|{Enfortumab vedotin-ejfv (solution)} Immunology/Inflammation|{Enfortumab vedotin-ejfv (solution)} Protocol|{Enfortumab vedotin-ejfv (solution)} Purity|{Enfortumab vedotin-ejfv (solution)} manufacturer|{Enfortumab vedotin-ejfv (solution)} Cancer}
CAS:
172747-50-1
Molecular Weight:
279.34
Formula:
C17H17N3O
Chemical Name:
4-[5-ethyl-2-(4-methoxyphenyl)-1H-imidazol-4-yl]pyridine
Smiles :
CCC1NC(=NC=1C1C=CN=CC=1)C1C=CC(=CC=1)OC
InChiKey:
MYKGURNPAUBQLJ-UHFFFAOYSA-N
InChi :
InChI=1S/C17H17N3O/c1-3-15-16(12-8-10-18-11-9-12)20-17(19-15)13-4-6-14(21-2)7-5-13/h4-11H,3H2,1-2H3,(H,19,20)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
SB 202474 is a structural analog of SB 202190 and SB 203580 that is used as a negative control in researches of p38 inhibition.{{D-Cycloserine} site|{D-Cycloserine} Antibiotic|{D-Cycloserine} Protocol|{D-Cycloserine} References|{D-Cycloserine} manufacturer|{D-Cycloserine} Autophagy} SB 202190 and SB 203580 are potent and selective inhibitors of the MAP kinases p38α and p38β . Mitogen-activated protein kinases (MAPKs) are ser/thr-specific protein kinases that regulate gene expression, proliferation, differentiation, cell survival and apoptosis. Three most widely characterized MAPK subfamilies are ERK1/2, JNK and p38MAPK, of which JNK and p38MAPK are identified as a stress-activated protein kinase (SAPK) that primarily mediates inflammatory response and promotes cell death . SB 202474 is a structural analog of SB 202190 and SB 203580 that is used as a negative control in researches of p38 inhibition.PMID:23557924 In 3T3-L1 adipocytes and L6 myotubes, SB203580 but not SB202474 prevented insulin-stimulated glucose transport . Pretreatment with microinjection into the bilateral rostral ventrolateral medulla (RVLM) of SB203580 (2 nmol) significantly exacerbated the depressor effect and blunted the augmented power density of the LF component of SAP signals during the pro-life phase. SB203580 also significantly shortened the pro-life phase to 60 min. SB202474 (2 nmol) was ineffective against the phasic cardiovascular responses in the aCSF-control group or Mev-experimental group .|Product information|CAS Number: 172747-50-1|Molecular Weight: 279.34|Formula: C17H17N3O|Chemical Name: 4-[5-ethyl-2-(4-methoxyphenyl)-1H-imidazol-4-yl]pyridine|Smiles: CCC1NC(=NC=1C1C=CN=CC=1)C1C=CC(=CC=1)OC|InChiKey: MYKGURNPAUBQLJ-UHFFFAOYSA-N|InChi: InChI=1S/C17H17N3O/c1-3-15-16(12-8-10-18-11-9-12)20-17(19-15)13-4-6-14(21-2)7-5-13/h4-11H,3H2,1-2H3,(H,19,20)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
