Product Name :
Flumexadol
Description:
Flumexadol is an orally active non-narcotic analgesic. Flumexadol is a selective and affinity 5-HT2C receptor agonist with a Ki of 25 nM for the (+)-enantiomer of Flumexadol, and is 40-fold selective over the 5-HT2A receptor.
CAS:
30914-89-7
Molecular Weight:
231.21
Formula:
C11H12F3NO
Chemical Name:
2-[3-(trifluoromethyl)phenyl]morpholine
Smiles :
FC(F)(F)C1=CC(=CC=C1)C1CNCCO1
InChiKey:
GXPYCYWPUGKQIJ-UHFFFAOYSA-N
InChi :
InChI=1S/C11H12F3NO/c12-11(13,14)9-3-1-2-8(6-9)10-7-15-4-5-16-10/h1-3,6,10,15H,4-5,7H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Flumexadol is an orally active non-narcotic analgesic. Flumexadol is a selective and affinity 5-HT2C receptor agonist with a Ki of 25 nM for the (+)-enantiomer of Flumexadol, and is 40-fold selective over the 5-HT2A receptor.|Product information|CAS Number: 30914-89-7|Molecular Weight: 231.21|Formula: C11H12F3NO|Chemical Name: 2-[3-(trifluoromethyl)phenyl]morpholine|Smiles: FC(F)(F)C1=CC(=CC=C1)C1CNCCO1|InChiKey: GXPYCYWPUGKQIJ-UHFFFAOYSA-N|InChi: InChI=1S/C11H12F3NO/c12-11(13,14)9-3-1-2-8(6-9)10-7-15-4-5-16-10/h1-3,6,10,15H,4-5,7H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 33.33 mg/mL (144.15 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Dihydroergotamine} site|{Dihydroergotamine} Neuronal Signaling|{Dihydroergotamine} Protocol|{Dihydroergotamine} References|{Dihydroergotamine} manufacturer|{Dihydroergotamine} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Voriconazole} site|{Voriconazole} Fungal|{Voriconazole} Purity & Documentation|{Voriconazole} Purity|{Voriconazole} manufacturer|{Voriconazole} Epigenetics} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23724934 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|In rats and dogs dosed with 14C-Flumexadol (CERM1841), the 14C is excreted in the urine. The 14C eliminated in the faeces of dog is significantly higher than for rat. Conjugated metabolites, mostly glucuronides, accounted for the greater part of the urinary radioactivity in both species. Biotransformation products are predominantly acids in both species, follows by significant amounts of basic metabolites, with very little neutral substances. The major urinary metabolite in rats is 3-trifluoromethylbenzoic acid and 3-trifluoromethylhipuric acid. In the dog it is 3-trifluoromethylmandelic acid in addition to the benzoic acid and its conjugate. The basic products identified in the urine of both species are unchanged drug and 1-amino-2-hydroxy-2-(3-trifluoromethylphenyl)ethane, with the first predominating.|Products are for research use only. Not for human use.|
