Product Name :
Trimethoprim lactate
Description:
Trimethoprim lactic is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim lactic is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim lactic has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment.
CAS:
23256-42-0
Molecular Weight:
380.40
Formula:
C17H24N4O6
Chemical Name:
2-hydroxypropanoic acid; 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
Smiles :
COC1C=C(CC2=CN=C(N)N=C2N)C=C(OC)C=1OC.CC(O)C(O)=O
InChiKey:
IIZVTUWSIKTFKO-UHFFFAOYSA-N
InChi :
InChI=1S/C14H18N4O3.C3H6O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-2(4)3(5)6/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2,4H,1H3,(H,5,6)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Trimethoprim lactic is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim lactic is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim lactic has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment.|Product information|CAS Number: 23256-42-0|Molecular Weight: 380.40|Formula: C17H24N4O6|Chemical Name: 2-hydroxypropanoic acid; 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine|Smiles: COC1C=C(CC2=CN=C(N)N=C2N)C=C(OC)C=1OC.CC(O)C(O)=O|InChiKey: IIZVTUWSIKTFKO-UHFFFAOYSA-N|InChi: InChI=1S/C14H18N4O3.C3H6O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-2(4)3(5)6/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2,4H,1H3,(H,5,6)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (657.20 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Acamprosate} medchemexpress|{Acamprosate} GABA Receptor|{Acamprosate} Purity & Documentation|{Acamprosate} Purity|{Acamprosate} supplier|{Acamprosate} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Epratuzumab} medchemexpress|{Epratuzumab} Immunology/Inflammation|{Epratuzumab} Purity & Documentation|{Epratuzumab} In Vitro|{Epratuzumab} manufacturer|{Epratuzumab} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23907521 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Trimethoprim interrupts folate metabolism by inhibition of the activity of dihydrofolase reductase (DHFR), which reduces dihydrofolate to tetrahydrofolate (THF). Trimethoprim causes protein aggregation and induction of main heat shock proteins (Hsps) in E. coli cells, which indicates that Trimethoprim presence leads to protein misfolding. Trimethoprim causes induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps. Among these Hsps, IbpA/B are most efficiently induced by Trimethoprim and coaggregates with the insoluble proteins. Upon folate stress, deletion of the delta ibpA/B operon resulted in increased protein aggregation but does not influence cell viability.|In Vivo:|In intraperitoneal infections in mice, the CD50 values for Trimethoprim alone against H. influenzae, S. pneumoniae, E. coli and N. meningitidis, is 150 mg/kg, 335 mg/kg, 27.5 mg/kg and 8.4 mg/kg, respectively.|Products are for research use only. Not for human use.|
