Product Name :
EGTA
Description:
EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages.
CAS:
67-42-5
Molecular Weight:
380.35
Formula:
C14H24N2O10
Chemical Name:
3,12-bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecanedioic acid
Smiles :
OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O
InChiKey:
DEFVIWRASFVYLL-UHFFFAOYSA-N
InChi :
InChI=1S/C14H24N2O10/c17-11(18)7-15(8-12(19)20)1-3-25-5-6-26-4-2-16(9-13(21)22)10-14(23)24/h1-10H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Elinzanetant} medchemexpress|{Elinzanetant} Neuronal Signaling|{Elinzanetant} Technical Information|{Elinzanetant} In Vivo|{Elinzanetant} supplier|{Elinzanetant} Cancer}
Shelf Life:
≥12 months if stored properly.{{Miconazole} site|{Miconazole} Anti-infection|{Miconazole} Biological Activity|{Miconazole} In stock|{Miconazole} supplier|{Miconazole} Epigenetic Reader Domain}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
EGTA is a specific calcium ion chelator.PMID:23537004 EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca2+ over Mg2+ (Mg2+ Kd 1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages.|Product information|CAS Number: 67-42-5|Molecular Weight: 380.35|Formula: C14H24N2O10|Chemical Name: 3,12-bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecanedioic acid|Smiles: OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O|InChiKey: DEFVIWRASFVYLL-UHFFFAOYSA-N|InChi: InChI=1S/C14H24N2O10/c17-11(18)7-15(8-12(19)20)1-3-25-5-6-26-4-2-16(9-13(21)22)10-14(23)24/h1-10H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 1 mg/mL (2.63 mM; Need ultrasonic). H2O : 10 mg/mL (26.29 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|EGTA, proposed as endodontic irrigant, decreases substrate adherence capacity of inflammatory macrophages in a time- and dose-dependent manner. The EGTA concentration that causes an IC50 is 202 mM. Chelators react with calcium ions in the hydroxyapatite crystals to produce a metallic chelate. Removal of calcium ions from the dentine makes the dentinal tissue softer, especially the hydroxyapatite-rich peritubular dentin and increases the diameter of exposed dentinal tubules.|Products are for research use only. Not for human use.|
