Product Name :
RGB-286638 free base
Description:
RGB-286638 is a multitargeted cyclin-dependent kinase inhibitor. RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs. GB-286638 treatment resulted in MM cytotoxicity in vitro associated with inhibition of MM tumor growth and prolonged survival in vivo. RGB-286638 displayed caspase-dependent apoptosis in both wt-p53 and mutant-p53 cells that was closely associated with the downregulation of RNA polymerase II phosphorylation and inhibition of transcription. RGB-286638 triggered p53 accumulation via nucleolar stress and loss of Mdm2, accompanied by induction of p53 DNA-binding activity.
CAS:
784210-88-4
Molecular Weight:
545.63
Formula:
C29H35N7O4
Chemical Name:
3-[3-(4-{[4-(2-methoxyethyl)piperazin-1-yl]methyl}phenyl)-4-oxo-1H,4H-indeno[1,2-c]pyrazol-5-yl]-1-(morpholin-4-yl)urea
Smiles :
COCCN1CCN(CC1)CC1=CC=C(C=C1)C1=NNC2C3=CC=CC(NC(=O)NN4CCOCC4)=C3C(=O)C1=2
InChiKey:
XLSYZSRXVVCHLS-UHFFFAOYSA-N
InChi :
InChI=1S/C29H35N7O4/c1-39-16-13-34-9-11-35(12-10-34)19-20-5-7-21(8-6-20)26-25-27(32-31-26)22-3-2-4-23(24(22)28(25)37)30-29(38)33-36-14-17-40-18-15-36/h2-8H,9-19H2,1H3,(H,31,32)(H2,30,33,38)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Ivermectin} web|{Ivermectin} Anti-infection|{Ivermectin} Protocol|{Ivermectin} References|{Ivermectin} manufacturer|{Ivermectin} Cancer}
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
RGB-286638 is a multitargeted cyclin-dependent kinase inhibitor.{{Labetuzumab} web|{Labetuzumab} Biological Activity|{Labetuzumab} References|{Labetuzumab} manufacturer|{Labetuzumab} Cancer} RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs.PMID:23776646 GB-286638 treatment resulted in MM cytotoxicity in vitro associated with inhibition of MM tumor growth and prolonged survival in vivo. RGB-286638 displayed caspase-dependent apoptosis in both wt-p53 and mutant-p53 cells that was closely associated with the downregulation of RNA polymerase II phosphorylation and inhibition of transcription. RGB-286638 triggered p53 accumulation via nucleolar stress and loss of Mdm2, accompanied by induction of p53 DNA-binding activity.|Product information|CAS Number: 784210-88-4|Molecular Weight: 545.63|Formula: C29H35N7O4|Chemical Name: 3-[3-(4-{[4-(2-methoxyethyl)piperazin-1-yl]methyl}phenyl)-4-oxo-1H,4H-indeno[1,2-c]pyrazol-5-yl]-1-(morpholin-4-yl)urea|Smiles: COCCN1CCN(CC1)CC1=CC=C(C=C1)C1=NNC2C3=CC=CC(NC(=O)NN4CCOCC4)=C3C(=O)C1=2|InChiKey: XLSYZSRXVVCHLS-UHFFFAOYSA-N|InChi: InChI=1S/C29H35N7O4/c1-39-16-13-34-9-11-35(12-10-34)19-20-5-7-21(8-6-20)26-25-27(32-31-26)22-3-2-4-23(24(22)28(25)37)30-29(38)33-36-14-17-40-18-15-36/h2-8H,9-19H2,1H3,(H,31,32)(H2,30,33,38)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
