SRP1 (3,5) PABPC1 (3,four,five) PAPOLA (three,five) PLCB1 (1,three,five) QKI (three,five) RNPS1 (1,3,5) SAFB (1,three,five) SART3 (3,five) SRSF5 (three,five) SRSF9 (three,5) SUPT5H (1,three,4,5) TRA2B (3,five)APERegulation of transcription (1) ABLIM3(1) AHI1 (1) AP2A2 (1) APP (1,2,three,five) ARID4A (1) ARRB1 (1) ATF2 (1,2) ATP2C1 (1) ATXN3 (1,two,three) BCAS3 (1) BCL6 (1) BRD3 (1) BRD8 (1) BRF1 (1) BRWD1 (1) BTRC (1) CASK (1) CBFA2T2 (1) CC2D1A (1) CD44 (1) CEBPZ (1) CENPK (1) CEP290 (1) CHD4 (1,4) COQ7 (1) CPSF3L (1,3) CREBZF (1) CTDSP2 (1) DAB2 (1) DAXX (1) DCLK2(1) DDX3X(1) DDX5 (1,three,5) DEK (1,two) DHX35 (1) DNAJB6 (1) DNMT1 (1,4) DNMT3B (1) E2F7 (1) ECSIT (1) EEF1D (1) EGF (1) EIF2B5 (1) ENY2 (1) ERBB2 (1,two) ERG (1) EWSR1 (1) EXOSC9 (1) FGFR1 (1) FKBP1A (1) FOSB (1) GCFC2 (1,3,five) GCLC (1) GTF2E2 (1) HDAC1 (1) HDAC4 (1) HDAC6 (1) HIVEP1 (1) HMGN1 (1,two,four) HNRNPA1 (1,3,5) HNRNPC (1,three,four,5) IFNAR2 (1) IFT74 (1) IKZF2 (1) ILK (1) INO80 (1,2) IRF3 (1) MAD1L1 (1) MAFF (1) MALT1 (1) MAP2K3 (1) MAP2K4 (1) MAPK3 (1) MAPK7 (1) MATR3 (1) MBD1 (1) MCF2L (1) MDM2 (1,two) MDM4 (1) MECOM (1) MED15 (1) MED26 (1) MEF2A (1) MEN1 (1) MKL1 (1) MLH1 (1,2,four) MLX (1) MXD3 (1) MYB (1) MYO6 (1) MZF1 (1) NARFL (1) NFATC3 (1) NFATC4 (1) (1) NFE2L1 (1,2) RASGRP1 (1) NFIC (1) REST (1,4) NIF3L1 (1) RFX5 (1) NR4A1 (1,2) RHOC (1) NUP62 (1) RNF10 (1) OSR2 (1) RNPS1 (1,three,5) PARK7 (1) RPAIN (1,2,four) PAWR (1) RPS6KB1 (1) PICALM (1) RSF1 (1) PITX2 (1) SAFB (1,three,5) PKD1 (1) SBNO2 (1) PLAGL1 (1) SLC2A4RG PLCB1 (1,three,5) (1) PLK1 (1) SLC9A1 (1) PLSCR1 (1) SMAD4 (1) PML (1) SMAD9 (1) POLR1B (1) SMARCA4 (1) PPP1R12A (1) SMARCAL1 PRDM4 (1) (1) PRMT5 (1) SMARCD3 PSMC5 (1) (1,2) PSRC1 (1) SNF8 (1) RALGAPA1 SORBS3 (1) SREBF2 (1) STAT6 (1) STUB1 (1) SUPT4H1 (1) SUPT5H (1,3,4,five) TAF1A (1) TARDBP (1,3) TCEB3C (contains other folks) (1) TCF3 (1) TDG (1,two) TERT (1,2,four) TFDP2 (1) TGFB1I1 (1) TIAL1 (1) TLE3 (1) TR73 (1,two) TRIM17 (1) TRIM6 (1) TRPS1 (1) TSC2 (1) UHRF1 (1,four) USF2 (1) VEGFA (1) WHSC1 (1) WWC1 (1) WWTR1 (1) XBP1 (1) YAP1 (1) ZBTB14 (1) ZEB1 (1) ZGPAT (1) ZNF12 (1) ZNF189 (1) ZNF205 (1) ZNF281 (1) ZNHIT3 (1)Fig.Galectin-9/LGALS9 Protein manufacturer 8 RIP identification of RNAs interacting with APE1.PFKM Protein Purity & Documentation Top-five functional annotation clusters of APE1 NA targets identified by Ingenuity Pathway Evaluation depending on functional terms of your “Biological Process” category.PMID:35670838 RNAs in more than 1 cluster are cross-referenced with numbersThese findings parallel our earlier data6, in which we observed that APE1 silencing, whilst blocking the Egr-1 mediated inducible expression of PTEN gene upon H2O2 or TSA remedies, was related using a paradoxical upregulation of your PTEN protein itself beneath basal situation. Now, we propose a model in which APE1 acts as a central player inside the homeostatic regulation of PTEN expression through transcriptional (by means of Egr-1) andNATURE COMMUNICATIONS | 8:post-transcriptional (through miR-221/22) counteracting mechanisms involved in a feedback autoregulatory loop. This model could be generalized to many genes regulated by APE1, whose expression was previously viewed as a kind of paradox3, six. These observations are also of certain interest for cancer improvement, in light of current papers in which APE1 expression has been correlated with low-PTEN expression in higher grade| DOI: 10.1038/s41467-017-00842-8 | nature.com/naturecommunicationsARTICLENATURE COMMUNICATIONS | DOI: ten.1038/s41467-017-00842-Table 2 By far the most enriched functional annotation disease clusters of APE1 NA targets identified by Ingenuity Pathway AnalysisDiseases Epithelial cancer Digestive method cancer.
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