Ira defluvii on a Proteobacteria tree forms a clade with Leptothrix cholodnii.Ricinus communis (Plantae) groups with Methylotenera mobilis PDDEXK_ PDDEXK_PF PFPfam PfamUnknown.In Fusobacteria DUF proteins are surrounded by mobile elements.This function is significantly less pronounced in other bacteria.Unknown.Initially claimed to bind RNA and abundant in Apicomplexans, present in proteins involved in mitochondrial pressure sensing and plant immunity .Located with bleomycin resistance (Glyoxalase) and Aceltyltransf_ (GNAT).In P.aeruginosa biofilms a YaeQ mutant has decreased expression of genes encoding NADH dehydrogenase activity and cobalamin biosynthetic procedure and increased expression of secretion and pathogenesis genes (e.g.exoY, pscU and exsC).This mutant has biofilmexclusive tobramycin fitness advantages.Tobramycin is an aminoglycoside antibiotic.YaeQ compensates or does not the hemolysin transcription elongation protein RfaH function.Putative transposase Unknown {} Bacteria Prokaryota VirusesPhylogeny not resolved Various transfers, mixed clades for Bacteria and Archaea or different Bacterial divisions (continued)Table .ContinuedPfam, COGKOG,PDB structureNo.Name Reference tofold assignmentBiological functionTaxonomyHGTsVirusesBacteriaArchaea PDDEXK_PFPfamUnknown DUF New New Putative transposase {} Unknown PFNewUnknown{} {} {} Bacteria DUFPFEukaryota Detailed distribution {} ProkaryotaRicinus communis (Plantae) is present inside a Proteobacteria clade.Parabacteroides merdae a human gut bacterium found also in wounds types a clade PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21569804 with a bacteria from termite hindguts Treponema primitia Populus balsamifera subsp.trichocarpa (Plantae) sequence forms a clade with a nonpathogenic metal resistant bacterium Ralstonia metallidurans Phylogeny not well resolveda Eukaryota Prokaryota Bacteria DUFPF Replic_Relax PFNew Damreplacing protein PF{}Bacteria (Bacillus Clostridium Actinobacteria) BacteriaMethanoplanus petrolearius (Euryarchaeota) and an uncultured archaeon find within a Bacteria (BacterioidetesActinobacteria) clade.Many transfers Streptococcus (Pleuromutilin Cancer Lactobacillales) locates within an Actinobacteria clade.Paenibacillus (Bacillales) sequence is discovered in an Actinobacteria clade Patchy distribution possibly due to a number of transfers Archaea (Thermococcales) No HGT observed TBPinteracting proteinczrPlasmid replication and {} plasmid DNA relaxation DNA adenine {} methyltransferase replacing protein (DRP), a restriction endonuclease A family members of proteins, that interact with TATAbinding protein (TBP) .Nucleic Acids Research, , Vol No.Groups contain closely associated families and structures that share fairly high sequence similarity detectable with PSIBLAST and RPSBLAST.a The tree was not rooted resulting from dubious position from the rooting sequence.The curly brackets inside the taxonomy columns indicate the amount of sequences if kingdom is represented only by a couple of sequences.Nucleic Acids Investigation, , Vol No.of PD(DE)XK proteins and offer a strong background for rational hypotheses about structurally unstudied families.Within the next section we describe numerous aspects of structural modifications that blur a typically recognized image of your restriction endonucleaselike proteins.Core variability The structural core of PD(DE)XK phosphodiesterase fold consists of only six big components 4 bstrands and two ahelices (Figure A).We believe that this minimalism contributes to structural diversity of the superfamily.The very first along with the second core bstrands can e.
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