Roxides [59]. Sterols, wich are the main constituents of PE extract, seemRoxides [59]. Sterols, wich

Roxides [59]. Sterols, wich are the main constituents of PE extract, seem
Roxides [59]. Sterols, wich are the main constituents of PE extract, seem to be most likely candidates for providing the observed antimutagenic activity of this extract [41]. Protective effect of PE, Chl and EA extracts 1-Deoxynojirimycin web against the tested mutagens may probably adsorb the mutagen in a way similar to the carcinogen adsorption which has been associated with pyrrole pigments, such as hemin and chlorophyllin [60,61]. The differents antimutagenic activity of Chl than EA and PE extracts could be explained by the antioxidant activity is often the result of the combined activity of a wide range of compounds, including phenolics, peptides, organic acids and other components [62] and to the different sensibilities of the two strains towards a given compound or complex [63].5. Conclusion In conclusion, the present study demonstrates that extracts of A. salicina possesses potent antioxidant and antimutagenic activities. These extract is capable of protecting against oxidative DNA damage. Further investigations on testing their in vivo activities and on isolation and characterization of the active compounds responsible for the antioxidant capacity of A. salicina leaf extracts are under way in our laboratory.Acknowledgements We acknowledge the ” Minist e Tunisien de l’Enseignement Sup ieur, de la Recherche et de la Technologie ” for the support of this study. Author details 1 Department of Cellular and Molecular Biology, Faculty of Dental Medicine, Rue Avicenne,Monastir, 5000, Tunisia. 2Department of Pharmacognosy, Faculty of Pharmacy, Rue Avicenne, Monastir, 5000, Tunisia.Boubaker et al. Annals of Clinical Microbiology and Antimicrobials 2011, PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/28499442 10:37 http://www.ann-clinmicrob.com/content/10/1/Page 9 ofAuthors’ contributions JB: Was responsible for the conception and design, testing and data acquisition, analysis and data interpretation and drafted the manuscript. HBM: Was responsible for the conception and design, testing and data acquisition, analysis and data interpretation and drafted the manuscript. The two first authors are contributed equally in this work KG: made substantial contribution to conception and revised it critically for important intellectual content. LCG: made substantial contribution to conception and revised it critically for important intellectual content. All authors read and approved the final manuscript. Conflict of interests statement The authors declare that they have no competing interests. Received: 20 September 2011 Accepted: 1 December 2011 Published: 1 December 2011 References 1. Bartolome A, Mandap K, David KJ, Sevilla F III, Villanueva J: SOS-red fluorescent protein (RFP) bioassay system for monitoring of antigenotoxic activity in plant extract. Biosens Bioelectron 2006, 21:2114-2120. 2. Fraga CG, Arias RF, Llessuy SF, Koch OR, Boveris A: Effect of vitamin E and seleniumdeficiency on rat liver chemiluminescence. Biochem J 1987, 2:383-386. 3. ramarathan N, OSAWA NT, Namiki M, Tashiro T: J SCI fOOD Agri 1986, 37:719. 4. Ben Sghair M, Boubaker J, Naffati Aicha, Limem I, Skandrani I, Bhouri W, Bouhlel I, Kilani S, Chekir Ghedira L, Ghedira K: Antimutagenic and Antioxidant Potentials of Teucrium Ramosissimum Essential Oil. Chem Biodiverity 2010, 7:1-10. 5. Johnson FB, Sinclair DA, Guarente L: Molecular biology of aging. Cell 1999, 2:291-302. 6. Gulcin I, Bursal E, Sehitoglu MH, Bilsel M, Goren AC: Polyphenol contents and antioxidant activity of lyophilized aqueous extract of propolis from Erzurum, Turkey. Food and Chem Tox.