Regarding patient-level factors, particularly preferences for treatment, and the methods for

Regarding patient-level factors, particularly preferences for treatment, and the methods for eliciting these are necessary to improve health care quality [6]. Recent studies have demonstrated differences in treatment choices between African-Americans and whites in medical conditions such as coronary artery disease, cervical cancer and end-stage OA [79]. In addition, the extent to which minority 6-Methoxybaicalein chemical information patients convey reluctance to accept proven treatments can contribute to health disparities [5]. Once identified, interventions can be designed to address racial/ethnic differences in patient decision-making. However, no study has examined racial/ethnic differences in treatment preferences among lupus patients. The primary objective of this study is to determine whether there are differences between African-American and white SLE patients’ willingness to (i) receive an immunosuppressive medication (i.e. CYC) when clinically indicated or (ii) participate in a clinical trial involving a novel, experimental medication. A second objective is to identify demographic, psychosocial and clinical characteristics associated with treatment preferences among SLE patients. Finally, we seek to determine whether demographic, psychosocial and clinical characteristics explain racial/ethnic differences in either measure of treatment preference. We hypothesize that compared with their white counterparts, African-American SLE patients will be less willing to accept aggressive medical management with CYC or participate in clinical trials involving novel, experimental medications. We also hypothesize that certain factors, including educational attainment, lack of familiarity with treatment and mistrust of the medical establishment contribute to these differences.during clinic visits from LOR-253MedChemExpress LT-253 November 2009 through December 2010. Only those who fulfilled the ACR SLE criteria (54 of 11) were included. The following were exclusion criteria: age <18 years, race other than African-American or white, history of taking CYC, history of participating in an interventional clinical trial involving a new medication and severe cognitive dysfunction. Patients who were not successfully contacted or failed to complete the majority of the survey were not included in the analysis (Fig. 1).Survey questionnaireInformed consents were obtained and telephone interview appointment dates were arranged during patient clinic visits. Sociodemographic and treatment preference data were obtained from structured telephone interviews. Following Bowling and Ebrahim's [6] model of treatment decision-making, we asked questions regarding specific variables that have been postulated and/or shown to explain racial or ethnic differences in treatment preferences in other medical conditions. The standardized survey is attached (see supplementary data, available at Rheumatology Online). Patient characteristics The following self-reported demographic information was collected: race/ethnicity, age, educational attainment, household income, employment status, medical insurance and marital status. The following personality and psychological characteristics were measured: Center for Epidemiologic Studies Depression (CES-D) self-reported depression scale [11] (range 153), prayer reliance [12] (range 02 for efficacy, 03 for usage) and Domain-Specific Risk Attitude Scale in health and safety [13] (range 1050). The Multidimensional Health Locus of Control [14] was determined in the following subscales: internal, chance and.Regarding patient-level factors, particularly preferences for treatment, and the methods for eliciting these are necessary to improve health care quality [6]. Recent studies have demonstrated differences in treatment choices between African-Americans and whites in medical conditions such as coronary artery disease, cervical cancer and end-stage OA [79]. In addition, the extent to which minority patients convey reluctance to accept proven treatments can contribute to health disparities [5]. Once identified, interventions can be designed to address racial/ethnic differences in patient decision-making. However, no study has examined racial/ethnic differences in treatment preferences among lupus patients. The primary objective of this study is to determine whether there are differences between African-American and white SLE patients' willingness to (i) receive an immunosuppressive medication (i.e. CYC) when clinically indicated or (ii) participate in a clinical trial involving a novel, experimental medication. A second objective is to identify demographic, psychosocial and clinical characteristics associated with treatment preferences among SLE patients. Finally, we seek to determine whether demographic, psychosocial and clinical characteristics explain racial/ethnic differences in either measure of treatment preference. We hypothesize that compared with their white counterparts, African-American SLE patients will be less willing to accept aggressive medical management with CYC or participate in clinical trials involving novel, experimental medications. We also hypothesize that certain factors, including educational attainment, lack of familiarity with treatment and mistrust of the medical establishment contribute to these differences.during clinic visits from November 2009 through December 2010. Only those who fulfilled the ACR SLE criteria (54 of 11) were included. The following were exclusion criteria: age <18 years, race other than African-American or white, history of taking CYC, history of participating in an interventional clinical trial involving a new medication and severe cognitive dysfunction. Patients who were not successfully contacted or failed to complete the majority of the survey were not included in the analysis (Fig. 1).Survey questionnaireInformed consents were obtained and telephone interview appointment dates were arranged during patient clinic visits. Sociodemographic and treatment preference data were obtained from structured telephone interviews. Following Bowling and Ebrahim's [6] model of treatment decision-making, we asked questions regarding specific variables that have been postulated and/or shown to explain racial or ethnic differences in treatment preferences in other medical conditions. The standardized survey is attached (see supplementary data, available at Rheumatology Online). Patient characteristics The following self-reported demographic information was collected: race/ethnicity, age, educational attainment, household income, employment status, medical insurance and marital status. The following personality and psychological characteristics were measured: Center for Epidemiologic Studies Depression (CES-D) self-reported depression scale [11] (range 153), prayer reliance [12] (range 02 for efficacy, 03 for usage) and Domain-Specific Risk Attitude Scale in health and safety [13] (range 1050). The Multidimensional Health Locus of Control [14] was determined in the following subscales: internal, chance and.