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Ne-releasing hormone. Endocrinology 105: 10071012. 14. Silman RE, Leone RM, Hooper RJ, Preece MA Melatonin, the pineal gland and human puberty. Nature 282: 301303. 15. de Holanda FS, Tufik S, Bignotto M, Maganhin CG, Vieira LH, et al. Evaluation of melatonin on the precocious puberty: a pilot study. Gynecol Endocrinol 27: 519523. 16. Crowley SJ, Acebo C, Carskadon MA Human puberty: salivary melatonin profiles 23148522 in continuous conditions. Dev Psychobiol 54: 468473. 17. Srinivasan V, Spence WD, Pandi-Perumal SR, Zakharia R, Bhatnagar KP, et al. Melatonin and human reproduction: shedding light on the darkness hormone. Gynecol Endocrinol 25: 779785. 18. van Geijlswijk IM, Mol RH, Egberts TC, Smits MG Evaluation of sleep, puberty and mental wellness in kids with long-term melatonin treatment for chronic idiopathic childhood sleep onset insomnia. Psychopharmacology 216: 111120. 19. Johnston JD, Messager S, Barrett P, Hazlerigg DG Melatonin action within the pituitary: neuroendocrine synchronizer and developmental modulator J Neuroendocrinol 15: 405408. 20. Johnston JD, Messager S, Ebling FJ, Williams LM, Barrett P, et al. Gonadotrophin-releasing hormone drives melatonin receptor down-regulation inside the establishing pituitary gland. Proc Natl Acad Sci U S A 100: 28312835. 21. Johnston JD, Schuster C, Barrett P, Hazlerigg DG Regulation on the ovine MT1 melatonin receptor promoter: interaction amongst several pituitary transcription components at various phases of improvement. Mol Cell Endocrinol 268: 5966. 22. Johnston JD, Klosen P, Barrett P, Hazlerigg DG Regulation of MT melatonin receptor expression in the foetal rat pituitary. J Neuroendocrinol 18: 5056. 23. Windle JJ, Weiner RI, Mellon PL Cell lines on the pituitary gonadotrope lineage derived by targeted oncogenesis in transgenic mice. Mol Endocrinol 4: 597603. 24. Veyrac A, Gros A, Bruel-Jungerman E, Rochefort C, Kleine Borgmann FB, et al. Zif268/egr1 gene controls the selection, maturation and functional integration of adult hippocampal newborn neurons by studying. Proc Natl Acad Sci U S A 110: 70627067. 25. Otway DT, Frost G, Johnston JD Circadian rhythmicity in murine preadipocyte and adipocyte cells. Chronobiol Int 26: 13401354. 26. Horn F, Bilezikjian LM, Perrin MH, Bosma MM, Windle 23408432 JJ, et al. Intracellular responses to gonadotropin-releasing hormone inside a clonal cell line from the gonadotrope lineage. Mol Endocrinol five: 347355. 27. Tremblay JJ, Drouin J Egr-1 is actually a downstream effector of GnRH and Epigenetics synergizes by direct interaction with Ptx1 and SF-1 to improve luteinizing hormone beta gene transcription. Mol Cell Biol 19: 25672576. 28. Barrett P, MacLean A, Davidson G, Morgan PJ Regulation with the Mel 1a melatonin receptor mRNA and protein levels within the ovine pars tuberalis: proof for a cyclic adenosine 39,59-monophosphate-independent Mel 1a receptor coupling and an autoregulatory mechanism of expression. Mol Endocrinol 10: 892902. 29. Ishii H, Sato S, Yin C, Sakuma Y, Kato M Cetrorelix, a gonadotropinreleasing hormone antagonist, induces the expression of melatonin receptor 1a within the gonadotropin-releasing hormone neuronal cell line GT1-7. Neuroendocrinology 90: 251259. 30. Liu J, Grogan L, Nau MM, Allegra CJ, Chu E, et al. Physical interaction amongst p53 and key response gene Egr-1. Int J Oncol 18: 863870. 31. Zhang F, Lin M, Abidi P, Thiel G, Liu J Particular interaction of Egr1 and c/EBPbeta leads to the transcriptional activation with the human low density Epigenetics lipoprotein receptor gene. J Biol.Ne-releasing hormone. Endocrinology 105: 10071012. 14. Silman RE, Leone RM, Hooper RJ, Preece MA Melatonin, the pineal gland and human puberty. Nature 282: 301303. 15. de Holanda FS, Tufik S, Bignotto M, Maganhin CG, Vieira LH, et al. Evaluation of melatonin around the precocious puberty: a pilot study. Gynecol Endocrinol 27: 519523. 16. Crowley SJ, Acebo C, Carskadon MA Human puberty: salivary melatonin profiles 23148522 in continual circumstances. Dev Psychobiol 54: 468473. 17. Srinivasan V, Spence WD, Pandi-Perumal SR, Zakharia R, Bhatnagar KP, et al. Melatonin and human reproduction: shedding light around the darkness hormone. Gynecol Endocrinol 25: 779785. 18. van Geijlswijk IM, Mol RH, Egberts TC, Smits MG Evaluation of sleep, puberty and mental overall health in children with long-term melatonin therapy for chronic idiopathic childhood sleep onset insomnia. Psychopharmacology 216: 111120. 19. Johnston JD, Messager S, Barrett P, Hazlerigg DG Melatonin action within the pituitary: neuroendocrine synchronizer and developmental modulator J Neuroendocrinol 15: 405408. 20. Johnston JD, Messager S, Ebling FJ, Williams LM, Barrett P, et al. Gonadotrophin-releasing hormone drives melatonin receptor down-regulation inside the building pituitary gland. Proc Natl Acad Sci U S A one hundred: 28312835. 21. Johnston JD, Schuster C, Barrett P, Hazlerigg DG Regulation on the ovine MT1 melatonin receptor promoter: interaction between a number of pituitary transcription elements at various phases of improvement. Mol Cell Endocrinol 268: 5966. 22. Johnston JD, Klosen P, Barrett P, Hazlerigg DG Regulation of MT melatonin receptor expression within the foetal rat pituitary. J Neuroendocrinol 18: 5056. 23. Windle JJ, Weiner RI, Mellon PL Cell lines of the pituitary gonadotrope lineage derived by targeted oncogenesis in transgenic mice. Mol Endocrinol four: 597603. 24. Veyrac A, Gros A, Bruel-Jungerman E, Rochefort C, Kleine Borgmann FB, et al. Zif268/egr1 gene controls the choice, maturation and functional integration of adult hippocampal newborn neurons by mastering. Proc Natl Acad Sci U S A 110: 70627067. 25. Otway DT, Frost G, Johnston JD Circadian rhythmicity in murine preadipocyte and adipocyte cells. Chronobiol Int 26: 13401354. 26. Horn F, Bilezikjian LM, Perrin MH, Bosma MM, Windle 23408432 JJ, et al. Intracellular responses to gonadotropin-releasing hormone in a clonal cell line with the gonadotrope lineage. Mol Endocrinol five: 347355. 27. Tremblay JJ, Drouin J Egr-1 can be a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to improve luteinizing hormone beta gene transcription. Mol Cell Biol 19: 25672576. 28. Barrett P, MacLean A, Davidson G, Morgan PJ Regulation of the Mel 1a melatonin receptor mRNA and protein levels in the ovine pars tuberalis: evidence for a cyclic adenosine 39,59-monophosphate-independent Mel 1a receptor coupling and an autoregulatory mechanism of expression. Mol Endocrinol 10: 892902. 29. Ishii H, Sato S, Yin C, Sakuma Y, Kato M Cetrorelix, a gonadotropinreleasing hormone antagonist, induces the expression of melatonin receptor 1a in the gonadotropin-releasing hormone neuronal cell line GT1-7. Neuroendocrinology 90: 251259. 30. Liu J, Grogan L, Nau MM, Allegra CJ, Chu E, et al. Physical interaction among p53 and key response gene Egr-1. Int J Oncol 18: 863870. 31. Zhang F, Lin M, Abidi P, Thiel G, Liu J Specific interaction of Egr1 and c/EBPbeta results in the transcriptional activation with the human low density lipoprotein receptor gene. J Biol.