In a sample of drug-dependent males, we examined the temporal sequence

In a AZD-8835 solubility sample of drug-dependent males, we examined the temporal sequence of events (situations, thoughts, feelings, behaviors) that preceded and that followed the occurrence of a first drug relapse (or a “close call”; Denne, Castro, Harris, 2001). Goals of This Methodological Description A major goal of the present IMM methodological description is to present issues and methods for the design and implementation of an IMM study (Castro Nieri, 2008). A second goal is to describe methodological adaptations of our original IMM approach (Castro Coe, 2007), which was originally developed using an earlier-generation text ARA290 chemical information analysis software program, TextSmart 1.1 (Statistical Package for the Social Sciences, 1997).2 We have adapted this IMM approach for use with a later-generation qualitative text analysis program, Atlas.ti (Muhr, 2004). Using selected cases from our ongoing studies, we will illustrate specific aspects of this IMM approach for conducting scientifically rigorous and culturally sensitive data analyses that integrate qualitative and quantitative data.NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author Manuscript1We wish to acknowledge the perspectives conveyed by Dr. Leona S. Aiken and graduate student Stephanie Moser from their exploration of hybrid models of health behavior that aim to incorporate emotion variables into classic cognitive models of health behavior. 2The original integrative mixed methods (IMM) methodology consisted of five steps: Step 1: Excluding nonrelevant terms. Eliminating irrelevant words (those with nonsubstantive meaning) such as articles (a, an, the) that occur at high frequency but offer no substantive meaning to the analysis. Step 2: Creating aliases. Aliases are words having similar meaning. For example, words such as “hot, sizzling, scalding,” all mean “very hot.” Step 3: Generating automatic categories. In TextSmart, thematic categories are generated via three methods: (a) frequency of response, (b) co-occurrence, or (c) both. Step 4: Iterative analysis toward an optimal solution. A general aim was to generate complex categories consisting of two or more words connected by “or,” such as: (“listens” or “elders”), for example, a traditional person, “listens to her elders.” Step 5: Dimensional coding. The final step in creating thematic variables was scale (dimensional) coding: (a) to apply levels or degree of intensity or emphasis to the identified category and (b) to conduct a validity check on any cases erroneously assigned under a given category.J Mix Methods Res. Author manuscript; available in PMC 2011 December 11.Castro et al.PageA Methodology for Integrative Mixed Methods StudiesOverviewNIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptThe IMM approach, as we have developed it, is implemented in six steps: (a) creating focus questions and conducting focus question interviews, (b) extracting response codes, (c) creating thematic categories (a “family” within Atlas.ti), (d) dimensionalizing the thematic category via scale coding, (e) qualitative uantitative data analysis, and (f) creating story lines (Castro Coe, 2007). As indicated, in Figure 2, the process of generating qualitative evidence (text data) involves the following: (a) eliciting verbal responses (Ri) to a specific focus question, (b) identifying response codes (Cj), (c) creating thematic categories (families; Fk), and (d) converting these categories into thematic variables (Vm; see Figure 2).In a sample of drug-dependent males, we examined the temporal sequence of events (situations, thoughts, feelings, behaviors) that preceded and that followed the occurrence of a first drug relapse (or a “close call”; Denne, Castro, Harris, 2001). Goals of This Methodological Description A major goal of the present IMM methodological description is to present issues and methods for the design and implementation of an IMM study (Castro Nieri, 2008). A second goal is to describe methodological adaptations of our original IMM approach (Castro Coe, 2007), which was originally developed using an earlier-generation text analysis software program, TextSmart 1.1 (Statistical Package for the Social Sciences, 1997).2 We have adapted this IMM approach for use with a later-generation qualitative text analysis program, Atlas.ti (Muhr, 2004). Using selected cases from our ongoing studies, we will illustrate specific aspects of this IMM approach for conducting scientifically rigorous and culturally sensitive data analyses that integrate qualitative and quantitative data.NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author Manuscript1We wish to acknowledge the perspectives conveyed by Dr. Leona S. Aiken and graduate student Stephanie Moser from their exploration of hybrid models of health behavior that aim to incorporate emotion variables into classic cognitive models of health behavior. 2The original integrative mixed methods (IMM) methodology consisted of five steps: Step 1: Excluding nonrelevant terms. Eliminating irrelevant words (those with nonsubstantive meaning) such as articles (a, an, the) that occur at high frequency but offer no substantive meaning to the analysis. Step 2: Creating aliases. Aliases are words having similar meaning. For example, words such as “hot, sizzling, scalding,” all mean “very hot.” Step 3: Generating automatic categories. In TextSmart, thematic categories are generated via three methods: (a) frequency of response, (b) co-occurrence, or (c) both. Step 4: Iterative analysis toward an optimal solution. A general aim was to generate complex categories consisting of two or more words connected by “or,” such as: (“listens” or “elders”), for example, a traditional person, “listens to her elders.” Step 5: Dimensional coding. The final step in creating thematic variables was scale (dimensional) coding: (a) to apply levels or degree of intensity or emphasis to the identified category and (b) to conduct a validity check on any cases erroneously assigned under a given category.J Mix Methods Res. Author manuscript; available in PMC 2011 December 11.Castro et al.PageA Methodology for Integrative Mixed Methods StudiesOverviewNIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptThe IMM approach, as we have developed it, is implemented in six steps: (a) creating focus questions and conducting focus question interviews, (b) extracting response codes, (c) creating thematic categories (a “family” within Atlas.ti), (d) dimensionalizing the thematic category via scale coding, (e) qualitative uantitative data analysis, and (f) creating story lines (Castro Coe, 2007). As indicated, in Figure 2, the process of generating qualitative evidence (text data) involves the following: (a) eliciting verbal responses (Ri) to a specific focus question, (b) identifying response codes (Cj), (c) creating thematic categories (families; Fk), and (d) converting these categories into thematic variables (Vm; see Figure 2).