Product Name :
EZH2-IN-4
Description:
EZH2-IN-4 is an orally active, potent EZH2 inhibitor with IC50s of 0.923 nM and 2.65 nM against wild type (WT) 5-membered (5-mer) EZH2 and mutant 5-mer EZH2, respectively. EZH2-IN-4 has anti-cancer activity.
CAS:
2088132-99-2
Molecular Weight:
511.72
Formula:
C29H41N3O3S
Chemical Name:
7-((4, 6-dimethyl-2-oxo-1, 2-dihydropyridin-3-yl)methyl)-2-((R)-1-((1r, 4R)-4-(3-methoxyazetidin-1-yl)cyclohexyl)ethyl)-3-methyl-4, 5, 6, 7-tetrahydro-8H-thieno[2, 3-c]azepin-8-one
Smiles :
C[C@H]([C@@H]1CC[C@H](CC1)N1CC(C1)OC)C1SC2=C(CCCN(CC3C(=O)NC(C)=CC=3C)C2=O)C=1C
InChiKey:
NSJLNLBLBQQSDY-CEMLEFRQSA-N
InChi :
InChI=1S/C29H41N3O3S/c1-17-13-18(2)30-28(33)25(17)16-31-12-6-7-24-20(4)26(36-27(24)29(31)34)19(3)21-8-10-22(11-9-21)32-14-23(15-32)35-5/h13,19,21-23H,6-12,14-16H2,1-5H3,(H,30,33)/t19-,21-,22-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
EZH2-IN-4 is an orally active, potent EZH2 inhibitor with IC50s of 0.923 nM and 2.65 nM against wild type (WT) 5-membered (5-mer) EZH2 and mutant 5-mer EZH2, respectively. EZH2-IN-4 has anti-cancer activity.|Product information|CAS Number: 2088132-99-2|Molecular Weight: 511.72|Formula: C29H41N3O3S|Chemical Name: 7-((4, 6-dimethyl-2-oxo-1, 2-dihydropyridin-3-yl)methyl)-2-((R)-1-((1r, 4R)-4-(3-methoxyazetidin-1-yl)cyclohexyl)ethyl)-3-methyl-4, 5, 6, 7-tetrahydro-8H-thieno[2, 3-c]azepin-8-one|Smiles: C[C@H]([C@@H]1CC[C@H](CC1)N1CC(C1)OC)C1SC2=C(CCCN(CC3C(=O)NC(C)=CC=3C)C2=O)C=1C|InChiKey: NSJLNLBLBQQSDY-CEMLEFRQSA-N|InChi: InChI=1S/C29H41N3O3S/c1-17-13-18(2)30-28(33)25(17)16-31-12-6-7-24-20(4)26(36-27(24)29(31)34)19(3)21-8-10-22(11-9-21)32-14-23(15-32)35-5/h13,19,21-23H,6-12,14-16H2,1-5H3,(H,30,33)/t19-,21-,22-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Protein G Agarose medchemexpress |Shelf Life: ≥12 months if stored properly.Temozolomide In Vivo |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32686511 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|EZH2-IN-4 (example 38) shows a cell H3K27me3 IC50 of 0.00973 nM in Karpas-422 (EZH2 Y641N) cells. EZH2-IN-4 shows an IC50 of 10.1 nM in Plate Kj«pas-422 cells. EZH2-IN-4 inhibits the proliferation of ovarian cancer cell lines (COV-434, TOV-21G, TOV-112D, A2780, Caov-3, OVCAR3; IC50s=0.02-8.6 μM) and has no effect on SKOV3, HeyA8, HEC59 cell (IC50>20 μM).|In Vivo:|EZH2-IN-4 (example 38; oral gavage; 15 mpk; BID) results in 73% inhibition of tumor methylation in the Karpas-422 xenograft model. EZH2-IN-4 (po; 50 mpk; twice a day; pretreatment for 5 days; followed by co-administration with gemcitabine plus cisplatin for at least 23 additional days) significant inhibits A2780 tumor growth in A2780 xenograft model.|Products are for research use only. Not for human use.|
