Product Name :
LY2606368 dihydrochloride
Description:
Prexasertib, also known as LY2606368, is a potent and selective Chk1/Chk2 inhibitor. Prexasertib increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia. LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms. Treatment of cells with LY2606368 results in the rapid appearance of TUNEL and pH2AX-positive double-stranded DNA breaks in the S-phase cell population.
CAS:
1234015-54-3
Molecular Weight:
438.31
Formula:
C18H21Cl2N7O2
Chemical Name:
5-(5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile dihydrochloride
Smiles :
Cl.Cl.COC1=CC=CC(OCCCN)=C1C1=CC(NC2=CN=C(C=N2)C#N)=NN1
InChiKey:
KMEIPKXRCJTZBZ-UHFFFAOYSA-N
InChi :
InChI=1S/C18H19N7O2.2ClH/c1-26-14-4-2-5-15(27-7-3-6-19)18(14)13-8-16(25-24-13)23-17-11-21-12(9-20)10-22-17;;/h2,4-5,8,10-11H,3,6-7,19H2,1H3,(H2,22,23,24,25);2*1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Cinacalcet CaSR
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Prexasertib, also known as LY2606368, is a potent and selective Chk1/Chk2 inhibitor. Prexasertib increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia.Bumetanide Description LY2606368 Causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms.PMID:32619361 Treatment of cells with LY2606368 results in the rapid appearance of TUNEL and pH2AX-positive double-stranded DNA breaks in the S-phase cell population.|Product information|CAS Number: 1234015-54-3|Molecular Weight: 438.31|Formula: C18H21Cl2N7O2|Synonym:|LY-2606368 dihydrochloride|Chemical Name: 5-(5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile dihydrochloride|Smiles: Cl.Cl.COC1=CC=CC(OCCCN)=C1C1=CC(NC2=CN=C(C=N2)C#N)=NN1|InChiKey: KMEIPKXRCJTZBZ-UHFFFAOYSA-N|InChi: InChI=1S/C18H19N7O2.2ClH/c1-26-14-4-2-5-15(27-7-3-6-19)18(14)13-8-16(25-24-13)23-17-11-21-12(9-20)10-22-17;;/h2,4-5,8,10-11H,3,6-7,19H2,1H3,(H2,22,23,24,25);2*1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
