Product Name :
Sclareol
Description:
Sclareol is a diterpene compound with a labdane skeleton, is mainly used as a raw material in the fragrance industry. It shows potent cytotoxic and cytostatic effect in human leukemic cell lines.
CAS:
515-03-7
Molecular Weight:
308.50
Formula:
C20H36O2
Chemical Name:
(1R, 2R, 4aS, 8aS)-1-((R)-3-hydroxy-3-methylpent-4-en-1-yl)-2, 5, 5, 8a-tetramethyldecahydronaphthalen-2-ol
Smiles :
CC1(C)CCC[C@@]2(C)[C@H]1CC[C@@](C)(O)[C@@H]2CC[C@@](C)(O)C=C
InChiKey:
XVULBTBTFGYVRC-HHUCQEJWSA-N
InChi :
InChI=1S/C20H36O2/c1-7-18(4,21)13-9-16-19(5)12-8-11-17(2,3)15(19)10-14-20(16,6)22/h7,15-16,21-22H,1,8-14H2,2-6H3/t15-,16+,18-,19-,20+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Mirogabalin} medchemexpress|{Mirogabalin} Calcium Channel|{Mirogabalin} Technical Information|{Mirogabalin} References|{Mirogabalin} manufacturer|{Mirogabalin} Cancer}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Sclareol is a diterpene compound with a labdane skeleton, is mainly used as a raw material in the fragrance industry. It shows potent cytotoxic and cytostatic effect in human leukemic cell lines.|Product information|CAS Number: 515-03-7|Molecular Weight: 308.50|Formula: C20H36O2|Chemical Name: (1R, 2R, 4aS, 8aS)-1-((R)-3-hydroxy-3-methylpent-4-en-1-yl)-2, 5, 5, 8a-tetramethyldecahydronaphthalen-2-ol|Smiles: CC1(C)CCC[C@@]2(C)[C@H]1CC[C@@](C)(O)[C@@H]2CC[C@@](C)(O)C=C|InChiKey: XVULBTBTFGYVRC-HHUCQEJWSA-N|InChi: InChI=1S/C20H36O2/c1-7-18(4,21)13-9-16-19(5)12-8-11-17(2,3)15(19)10-14-20(16,6)22/h7,15-16,21-22H,1,8-14H2,2-6H3/t15-,16+,18-,19-,20+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 61 mg/mLwarmed(197.73 mM). Water: Insoluble.|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.{{Adecatumumab} site|{Adecatumumab} Activator|{Adecatumumab} Purity & Documentation|{Adecatumumab} Description|{Adecatumumab} supplier} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24631563 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts antitumor effects in various cell lines. Sclareol is able to inhibit DNA synthesis induce arrest at the G(0/1) phase of the cycle apoptosis independent of p53 in human breast cancer cell lines. Intra-tumoral injection of Sclareol reduces tumor growth in vivo against breast cancer. Sclareol also exhibits anti-inflammatory activity in LPS-stimulated macrophages by decreasing inflammatory cytokines expression and increasing antioxidant enzyme activity.|In Vivo:|LD50: Rats >5g/kg (i.g.)|References:|Huang GJ, et al. J Nat Prod, 2012, 75(1), 54-59.Noori S, et al. Cell Immunol, 2010, 263(2), 148-153.Dimas K, et al. Biomed Pharmacother, 2006, 60(3), 127-133.Products are for research use only. Not for human use.|
