Product Name :
A 438079
Description:
A-438079 is a P2X7 receptor antagonist. A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation. A-438079 partially but significantly prevented the 6-OHDA-induced depletion of striatal DA stores. P2X7R inhibitor A-438079 reduced electrographic and clinical seizure severity during status epilepticus and reduced seizure-induced neuronal death in the neocortex. Blockade of P2X(7) receptors may represent a novel protective strategy for striatal DA terminals in Parkinson’s disease.
CAS:
899507-36-9
Molecular Weight:
306.15
Formula:
C13H9Cl2N5
Chemical Name:
3-{[5-(2,3-dichlorophenyl)-1H-1,2,3,4-tetrazol-1-yl]methyl}pyridine
Smiles :
ClC1=CC=CC(C2=NN=NN2CC2=CN=CC=C2)=C1Cl
InChiKey:
MMPAULQSJLVKHP-UHFFFAOYSA-N
InChi :
InChI=1S/C13H9Cl2N5/c14-11-5-1-4-10(12(11)15)13-17-18-19-20(13)8-9-3-2-6-16-7-9/h1-7H,8H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.{{Atomoxetine} medchemexpress|{Atomoxetine} Sodium Channel|{Atomoxetine} Protocol|{Atomoxetine} In stock|{Atomoxetine} manufacturer|{Atomoxetine} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
A-438079 is a P2X7 receptor antagonist. A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation. A-438079 partially but significantly prevented the 6-OHDA-induced depletion of striatal DA stores. P2X7R inhibitor A-438079 reduced electrographic and clinical seizure severity during status epilepticus and reduced seizure-induced neuronal death in the neocortex. Blockade of P2X(7) receptors may represent a novel protective strategy for striatal DA terminals in Parkinson’s disease.|Product information|CAS Number: 899507-36-9|Molecular Weight: 306.15|Formula: C13H9Cl2N5|Chemical Name: 3-{[5-(2,3-dichlorophenyl)-1H-1,2,3,4-tetrazol-1-yl]methyl}pyridine|Smiles: ClC1=CC=CC(C2=NN=NN2CC2=CN=CC=C2)=C1Cl|InChiKey: MMPAULQSJLVKHP-UHFFFAOYSA-N|InChi: InChI=1S/C13H9Cl2N5/c14-11-5-1-4-10(12(11)15)13-17-18-19-20(13)8-9-3-2-6-16-7-9/h1-7H,8H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Dipotassium glycyrrhizinate} site|{Dipotassium glycyrrhizinate} Virus Protease|{Dipotassium glycyrrhizinate} Technical Information|{Dipotassium glycyrrhizinate} Formula|{Dipotassium glycyrrhizinate} supplier|{Dipotassium glycyrrhizinate} Epigenetic Reader Domain} |Shelf Life: ≥360 days if stored properly.PMID:23522542 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
