Product Name :
Peptide 78
Description:
Peptide 78 identical to peptide 74 except that serine replaces cysteine; does not inhibit 72-kDa type IV collagenase. Peptide 78, a chemotactic cytokine, a 78 amino acid protein member of the IL-8 or C-X-C chemokine supergene family. ENA-78 plays an important role in the elicitation of predominantly neutrophils (PMNs) into the joints of rheumatoid arthritis (RA)
CAS:
132116-62-2
Molecular Weight:
1487.68
Formula:
C60H106N22O20S
Chemical Name:
(3S)-3-{[(2S)-1-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S, 3R)-2-amino-3-hydroxybutanamido]-4-(methylsulfanyl)butanamido]-5-carbamimidamidopentanamido]hexanamido]-5-carbamimidamidopentanamido]-3-hydroxypropanamido]acetamido}-3-carbamoylpropanoyl]pyrrolidin-2-yl]formamido}-3-{[(1S)-1-{[(1S)-1-{[(1S)-2-carbamoyl-1-carboxyethyl](propyl)carbamoyl}ethyl]carbamoyl}-2-methylpropyl]carbamoyl}propanoic acid
Smiles :
CC(C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N(CCC)[C@@H](CC(N)=O)C(O)=O
InChiKey:
OPKCDFWAZKOPFX-OMBAYSRHSA-N
InChi :
InChI=1S/C60H106N22O20S/c1-7-21-81(40(58(101)102)26-42(63)86)56(99)30(4)72-55(98)46(29(2)3)80-52(95)36(25-44(88)89)78-53(96)39-16-12-22-82(39)57(100)37(24-41(62)85)73-43(87)27-71-47(90)38(28-83)79-50(93)34(15-11-20-70-60(67)68)75-48(91)32(13-8-9-18-61)74-49(92)33(14-10-19-69-59(65)66)76-51(94)35(17-23-103-6)77-54(97)45(64)31(5)84/h29-40,45-46,83-84H,7-28,61,64H2,1-6H3,(H2,62,85)(H2,63,86)(H,71,90)(H,72,98)(H,73,87)(H,74,92)(H,75,91)(H,76,94)(H,77,97)(H,78,96)(H,79,93)(H,80,95)(H,88,89)(H,101,102)(H4,65,66,69)(H4,67,68,70)/t30-,31+,32-,33-,34-,35-,36-,37-,38-,39-,40-,45-,46-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Peptide 78 identical to peptide 74 except that serine replaces cysteine; does not inhibit 72-kDa type IV collagenase.{{Eugenol} web|{Eugenol} Bacterial|{Eugenol} Technical Information|{Eugenol} Formula|{Eugenol} custom synthesis|{Eugenol} Cancer} Peptide 78, a chemotactic cytokine, a 78 amino acid protein member of the IL-8 or C-X-C chemokine supergene family.{{Hemocyanin} MedChemExpress|{Hemocyanin} Metabolic Enzyme/Protease|{Hemocyanin} Technical Information|{Hemocyanin} Description|{Hemocyanin} manufacturer|{Hemocyanin} Epigenetics} ENA-78 plays an important role in the elicitation of predominantly neutrophils (PMNs) into the joints of rheumatoid arthritis (RA)|Product information|CAS Number: 132116-62-2|Molecular Weight: 1487.68|Formula: C60H106N22O20S|Chemical Name: (3S)-3-{[(2S)-1-[(2S)-2-{2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-[(2S, 3R)-2-amino-3-hydroxybutanamido]-4-(methylsulfanyl)butanamido]-5-carbamimidamidopentanamido]hexanamido]-5-carbamimidamidopentanamido]-3-hydroxypropanamido]acetamido}-3-carbamoylpropanoyl]pyrrolidin-2-yl]formamido}-3-{[(1S)-1-{[(1S)-1-{[(1S)-2-carbamoyl-1-carboxyethyl](propyl)carbamoyl}ethyl]carbamoyl}-2-methylpropyl]carbamoyl}propanoic acid|Smiles: CC(C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N(CCC)[C@@H](CC(N)=O)C(O)=O|InChiKey: OPKCDFWAZKOPFX-OMBAYSRHSA-N|InChi: InChI=1S/C60H106N22O20S/c1-7-21-81(40(58(101)102)26-42(63)86)56(99)30(4)72-55(98)46(29(2)3)80-52(95)36(25-44(88)89)78-53(96)39-16-12-22-82(39)57(100)37(24-41(62)85)73-43(87)27-71-47(90)38(28-83)79-50(93)34(15-11-20-70-60(67)68)75-48(91)32(13-8-9-18-61)74-49(92)33(14-10-19-69-59(65)66)76-51(94)35(17-23-103-6)77-54(97)45(64)31(5)84/h29-40,45-46,83-84H,7-28,61,64H2,1-6H3,(H2,62,85)(H2,63,86)(H,71,90)(H,72,98)(H,73,87)(H,74,92)(H,75,91)(H,76,94)(H,77,97)(H,78,96)(H,79,93)(H,80,95)(H,88,89)(H,101,102)(H4,65,66,69)(H4,67,68,70)/t30-,31+,32-,33-,34-,35-,36-,37-,38-,39-,40-,45-,46-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23667820 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Peptide 78 identical to peptide 74 except that serine replaces cysteine; does not inhibit 72-kDa type IV collagenase.|References:|Li Z, Wang Z, Zhang C, Chen J, Su Y, Huang J, Yi Z, Yuan C, Hong W, Wang Y, Wu Z, Hu Y, Cao L, Peng D, Guan Y, Zou Y, Yu S, Cui D, Fang Y. Reduced ENA78 levels as novel biomarker for major depressive disorder and venlafaxine efficiency: Result from a prospective longitudinal study. Psychoneuroendocrinology. 2017 Jul;81:113-121. doi: 10.1016/j.psyneuen.2017.03.015. Epub 2017 Mar 18. PubMed PMID: 28441588.Liu L, Chowdhury S, Fang X, Liu JL, Srikant CB. Attenuation of unfolded protein response and apoptosis by mReg2 induced GRP78 in mouse insulinoma cells. FEBS Lett. 2014 May 29;588(11):2016-24. doi: 10.1016/j.febslet.2014.04.030. Epub 2014 May 4. PubMed PMID: 24801175.Products are for research use only. Not for human use.|
