Product Name :
5′-deoxy Thymidine
Description:
5′-Deoxy Thymidine has been used as a research tool for antiviral and anticancer studies. 5′-Deoxy Thymidine can be used to study the entry mechanism into human erythrocytes in comparison with other deoxythymidines. Deoxythymidine, also named as thymidine, is the DNA nucleoside T. Deoxythymidine can pair with deoxyadenosine (A) in double-stranded DNA. 5′-deoxy Thymidine is a form of thymidine which had the hydroxyl group at the 5′ position replaced with hydrogen . 5′-deoxy Thymidine (50 μg/mL) was effective against Bacillus subtilis and Staphylococcus aureus . The MBC of 5′-deoxy Thymidine was 50 μg/mL. 5′-deoxy Thymidine has been used as an antibacterial agent in medical situations . Thymidine has been phosphorylated at the hydroxyl group on carbon 5 of the ribose moiety before polymerization into DNA. 5′-Deoxy Thymidine cannot be phosphorylated and used by DNA polymerase in the synthesis of DNA. In human erythrocytes, 5′-Deoxy Thymidine was readily and nonconcentratively uptaked by metabolism, and could be partially inhibited by nucleosides or inhibitors of nucleoside transport at micromolar concentrations .
CAS:
3458-14-8
Molecular Weight:
226.23
Formula:
C10H14N2O4
Chemical Name:
1-[(2R,4S,5R)-4-hydroxy-5-methyloxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
Smiles :
CC1=CN([C@H]2C[C@H](O)[C@@H](C)O2)C(=O)NC1=O
InChiKey:
UGUILUGCFSCUKR-GJMOJQLCSA-N
InChi :
InChI=1S/C10H14N2O4/c1-5-4-12(10(15)11-9(5)14)8-3-7(13)6(2)16-8/h4,6-8,13H,3H2,1-2H3,(H,11,14,15)/t6-,7+,8-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
5′-Deoxy Thymidine has been used as a research tool for antiviral and anticancer studies. 5′-Deoxy Thymidine can be used to study the entry mechanism into human erythrocytes in comparison with other deoxythymidines. Deoxythymidine, also named as thymidine, is the DNA nucleoside T. Deoxythymidine can pair with deoxyadenosine (A) in double-stranded DNA. 5′-deoxy Thymidine is a form of thymidine which had the hydroxyl group at the 5′ position replaced with hydrogen . 5′-deoxy Thymidine (50 μg/mL) was effective against Bacillus subtilis and Staphylococcus aureus . The MBC of 5′-deoxy Thymidine was 50 μg/mL. 5′-deoxy Thymidine has been used as an antibacterial agent in medical situations . Thymidine has been phosphorylated at the hydroxyl group on carbon 5 of the ribose moiety before polymerization into DNA. 5′-Deoxy Thymidine cannot be phosphorylated and used by DNA polymerase in the synthesis of DNA. In human erythrocytes, 5′-Deoxy Thymidine was readily and nonconcentratively uptaked by metabolism, and could be partially inhibited by nucleosides or inhibitors of nucleoside transport at micromolar concentrations .|Product information|CAS Number: 3458-14-8|Molecular Weight: 226.{{Tricin} MedChemExpress|{Tricin} Anti-infection|{Tricin} Technical Information|{Tricin} In Vitro|{Tricin} supplier|{Tricin} Autophagy} 23|Formula: C10H14N2O4|Chemical Name: 1-[(2R,4S,5R)-4-hydroxy-5-methyloxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione|Smiles: CC1=CN([C@H]2C[C@H](O)[C@@H](C)O2)C(=O)NC1=O|InChiKey: UGUILUGCFSCUKR-GJMOJQLCSA-N|InChi: InChI=1S/C10H14N2O4/c1-5-4-12(10(15)11-9(5)14)8-3-7(13)6(2)16-8/h4,6-8,13H,3H2,1-2H3,(H,11,14,15)/t6-,7+,8-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Busulfan} site|{Busulfan} Cell Cycle/DNA Damage|{Busulfan} Technical Information|{Busulfan} Data Sheet|{Busulfan} custom synthesis|{Busulfan} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:22664133 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
