N ventricular geometry endure for a prolonged period. Second, detailed assessments

N ventricular geometry endure for a prolonged period. Second, detailed assessments could be performed using several techniques to provide better insight into the nature of functional benefits associated with the procedure: echocardiography to track regional LV wall motion and provide more detailed geometric analysis (eg, sphericity index); magnetic resonance imaging to investigate LV geometry and provide accurate LV volumes with the cardiac cycle; positron emission tomography/magnetic resonance imaging to assess cardiac metabolism; and invasive hemodynamic monitoring to obtain functional parameters such as dP/dt max or preload/afterload-corrected echocardiographic evaluation. Third, postmortem infarct size and fibrosis measurements are lacking in the study. Finally, this study does not address the optimal timing for patch implantation or the optimal rate for material degradation. Performing the patch plasty procedure sooner after MI (eg, withinJ Thorac Cardiovasc Surg. Author manuscript; available in PMC 2013 August 01.NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptHashizume et al.Pagedays as opposed to 2 weeks) may produce better functional preservation. Whether a faster or slower degrading patch would provide improved benefit is also undetermined, as is the optimal elastic stiffness of the material to be applied. In conclusion, PEUU patch implantation prevented LV dilatation, preserved contractile function, and improved the retention of wall thickness in the infarcted LV wall. Improved vascularity was observed in the patched LV wall. These data in a large animal model are consistent with our previous results in small animals and suggest that PEUU patch placement may be efficacious for cardiomyoplasty of the chronically infarcted LV wall by altering the adverse remodeling process and, at least temporarily, preserving myocardial function. We thank Jennifer Debarr, Keisuke Takanari, Hong-bin Jiang, and Deanna L. Rhoads for their help with the tissue histological assessment, David Fischer, Judith L. Thoma, and Takeyoshi Ota for their excellent assistance with the animal procedures, Tomomi Yamada for her statistical evaluation, and Joseph E. Pichamuthu for his help on the cyclic tensile testing.NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptSupplementary MaterialRefer to Web version on PubMed Central for supplementary material.AcknowledgmentsFunded by the National Heart, Lung and Blood Institute, National Institutes of Health grant HL069368.Abbreviations and AcronymsSMA EDA EF ESA FAC LV LVEDV LVESV MI PEUU -smooth muscle actin end-diastolic area ejection fraction end-systolic area fractional area change left ventricular (ventricle) left ventricular end-diastolic volume left ventricular end-systolic volume myocardial infarction poly(ester urethane)urea;
Asian-Aust.Teneligliptin J.Galanthamine Anim.PMID:23833812 Sci.Vol. 26, No. 4 : 501-508 Aprilhttp://dx.doi.org/10.5713/ajas.2012.www.ajas.infopISSN 1011-2367 eISSN 1976-Effect of Dipeptides on In vitro Maturation, Fertilization and Subsequent Embryonic Development of Porcine OocytesK. M. A. Tareq1,2, Quzi Sharmin Akter3, Hirotada Tsujii4, M. A. M. Yahia Khandoker5 and Inho Choi1,* 1 School of Biotechnology, Yeungnam University, Gyeongsan 712-749, Korea ABSTRACT: The effects of amino acids and dipeptides on in vitro production of porcine embryos and accumulation of ammonia inculture medium during developmental stages were examined in this study. The maturation, fertilization.