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Rown Agent; 1966. 4. Malek SN, Phang CW, Ibrahim H, Norhanom W, Sim KS: Phytochemical and cytotoxic investigations of Alpinia mutica rhizomes. Molecules 2011, 16:58389. 5. Ghosh S, Rangan L: Alpinia: the gold mine of future therapeutics. three Biotech 2013, 3:13. 6. Awang K, Ibrahim H, Rosmy Syamsir D, Mohtar M, Mat Ali R, Azah Mohamad Ali N: Chemical constituents and antimicrobial activity on the leaf and rhizome oils of Alpinia pahangensis Ridl., an endemic wild ginger from peninsular Malaysia. Chem Biodivers 2011, 8:66873. 7. Paz-Elizur T, Sevilya Z, Leitner-Dagan Y, Elinger D, Roisman LC, Livneh Z: DNA repair oxidative DNA damage in human carcinogenesis: possible application for cancer risk assessment and prevention. Cancer Lett 2008, 266:602. 8. Moreira P, Smith MA, Zhu X, Honda K, Lee HG, Aliev G, Perry G: Considering the fact that oxidative harm is often a important phenomenon in Alzheimer’s disease, treatment with antioxidants seems to become a promising method for slowing illness progression. Oxidative harm and Alzheimer’s disease: are antioxidant therapies valuable Drug News Perspect 2005, 18:139. 9. Liu J, Mori A: Oxidative damage hypothesis of stress-associated aging acceleration: neuroprotective effects of organic and nutritional antioxidants. Res Commun Biol Psychol Psychiat Neurosci 2006, 31:10319. 10. Naito Y, Uchiyama K, Yoshikawa T: Oxidative stress involvement in diabetic nephropathy and its prevention by astaxanthin. Oxid Strain Disease 2006, 21:23542. 11. Jain SK: Superoxide dismutase overexpression and cellular oxidative damage in diabetes. A commentary overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes. Absolutely free Rad Biol Med 2006, 41:1187190. 12. Beal MF: Mitochondria, oxidative damage, and inflammation in Parkinson’s illness. Ann N Y Acad Sci 2003, 991:12031. 13. Heinecke JW: Mechanisms of oxidative harm of low density lipoprotein in human atherosclerosis. Curr Opin Lipidol 1997, 8:26874. 14. Halliwell B: The best way to characterize a biological antioxidant. Free of charge Rad Res Commun 1990, 9:12. 15. Halliwell B: Antioxidants: the basic- what they’re and how you can evaluate them. Adv Pharmacol 1997, 38:30. 16. Volka M, Rhodes CJ, Moncol J, Izakovic M, Mazur M: Absolutely free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006, 160:ten. 17. Niki E: Assessment of antioxidant capacity in vitro and vivo.Boc-L-Ala-OH Protocol Absolutely free Rad Biol Med 2010, 49:50315.Conclusions This function describes for the first time the in vitro antioxidant and cytotoxic activity from the rhizomes of Alpinia pahangensis. The rhizomes showed good antioxidant capacity when evaluated against 5 antioxidant assays.Dapiglutide References The ethyl acetate fraction showed excellent DPPH radical scavenging and superoxide anion scavenging activities while the crude methanol extract possessed fantastic lowering energy capability pretty much comparable to that with the requirements BHA and ascorbic acid, and great -carotene bleaching activity.PMID:24883330 In contrast, the hexane extract showed good antiproliferative activity against KB and Ca Ski cell lines but weak antioxidant activity. It can as a result be concluded that the rhizomes of Alpinia pahangensis possess the potential to be utilized as chemopreventive and chemotherapeutic agent and consumption of these rhizomes may well supply some overall health positive aspects. Further investigation around the underlying mechanism accountable for the biological activities needs to be attempted.Abbreviations DPPH: two,2-diphenyl-1-picrylhydrazyl; SOD: Superoxide dismutase; GC-MS: Gas chromatography as.

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