Within a damaging feedback loop, in which binding of a EGFR/ErbB family Proteins MedChemExpress ligand to its receptor inhibits expression with the ligand (A); a positive feed-forward loop, in which binding of a ligand to its receptor increases expression from the ligand (B); self-stimulation, that is frequently observed in immune cells (eg, interleukin [IL] 2 in T lymphocytes) (C); and transactivation, in which activation of a cell with a certain element begins production of a second autocrine
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