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Publisher’s Note: MDPI stays neu tral with regard to jurisdictional claims in published maps and institu tional affiliations.Copyright: 2021 by the authors. Li censee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and con ditions in the Inventive Commons At tribution (CC BY) license (http://crea tivecommons.org/licenses/by/4.0/).Marphysa sanguinea is really a widely distributed polychaete within the sedimentary zone of in tertidal locations worldwide. As a Tianeptine sodium salt Epigenetic Reader Domain dominant species that lives in the rock block from the upper and low intertidal regions, M. sanguinea feeds on organic debris and benthic macroalgae. The worm and its larvae are appropriate food for marine predatory fish and shrimp. As a result, M. sanguinea is definitely an crucial species in energy flow and substance circulation in intertidal ecology systems. M. sanguinea is utilised as an essential bioremediation species to the pol luted marine sediment environment resulting from its ability to biotransform organic pollutants, and some molecular markers are used as a sentinel indicator for pollution in coastal sed iments [1]. Following the development of aquatic industries and recreational fisheries, M. sanguinea is utilised broadly as an excellent meals supply for factorycultured crustaceans and exceptional bait that is well-known amongst the public and features a high price within the marketplace [5,6]. The price tag of M. sanguinea is around one hundred US dollars (USD) per kilogram in Japan, South Korea and Europe, and this species is generally known as on the list of top expensiveFishes 2021, 6, 52. https://doi.org/10.3390/fisheswww.mdpi.com/journal/fishesFishes 2021, 6,two ofpolychaete worms inside the world [7]. As an indispensable member of marine drug.